Chief Medical Officer – Biotech
San Francisco, CA or Boston, MA
We are seeking a Chief Medical Officer to lead clinical development strategy for an innovative biotech company advancing programs in oncology/hematology. This role is ideal for a physician executive with deep drug development experience and a track record advancing assets from IND through proof-of-concept and beyond.
Key Responsibilities
- Lead overall clinical development strategy across the portfolio, including first-in-human through later-stage studies.
- Provide medical leadership for protocol design, dose escalation strategy, safety review, and clinical data interpretation.
- Serve as strategic lead for interactions with FDA, EMA, and other health authorities, including regulatory submissions and development planning.
- Oversee and help build clinical development, clinical science, and medical affairs capabilities.
- Partner closely with translational, regulatory, biometrics, and executive leadership to shape development strategy and portfolio decisions.
- Drive KOL engagement, advisory boards, investigator relationships, and scientific communication strategy.
- Support safety oversight, benefit-risk assessment, and data-driven go/no-go decisions.
Contribute to Board presentations, investor diligence, and broader corporate strategy.
Qualifications
- MD required; board certification in Medical Oncology, Hematology, Hematology/Oncology, or another relevant specialty strongly preferred.
- 15+ years of biopharma clinical development experience, including senior medical leadership roles.
- Demonstrated experience advancing oncology or hematology programs through IND, Phase I/II development, and proof-of-concept milestones.
- Experience serving as medical lead for early phase dose escalation studies, including exposure-response, safety review, and development strategy.
- Prior experience with solid tumors, hematologic malignancies, cell therapy, radiopharmaceuticals, ADCs, or immuno-oncology
- Track record of regulatory interactions with FDA and other global agencies.
Experience in early-stage or venture-backed biotech environments preferred.